http://www.mattheyseslab.com/people daily 0.75 2026-01-23 https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/b999e92e-68e0-44b4-a5dd-fd6f230e8cac/IMG_2085.jpg People - Alexa L. Mattheyses, PhD Professor Department of Cell, Developmental, and Integrative Biology Department of Dermatology (Secondary) Director, High Resolution Imaging Facility (HRIF) Microscopy Core Ph.D. University of Michigan B.A. Smith College email: mattheyses [at] uab.edu https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/966583d7-68ac-419e-befe-4e22f20f1e15/IMG_5266+%281%29.jpg People - Leslie Donoghue Seeley, PhD Ph.D. UAB (Biomedical Engineering) B.S. University of Alabama, Tuscaloosa (Chemical and Biological Engineering) email: lesdon [at] uab.edu https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/908f9607-47cc-43d6-aeeb-d52c0ea95c35/Picture1.jpg People - Collin Ainslie, MS UAB GBS, Genetics, Genomics, and Bioinformatics Theme M.S. University of Alabama at Birmingham, Multidisciplinary Biomedical Science B.S. University of Alabama in Huntsville, Biological Sciences Email: ainsliec [at] uab.edu Twitter: Ainslie_col https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/a1ecd687-c6d4-43e9-b902-580614757c90/PXL_20250313_144954099.jpg People - Samuel Bartley, MS UAB GBS, Neuroscience Theme M.S. Northwestern University, Neurobiology B.S. Indiana University, Neuroscience Email: sbartle2 [at] usb.edu https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/607d8ff6-fd3d-4495-ad80-ca0b71b5e51c/IMG_20220906_090732.jpg People - Jie Yuan UAB Biomedical Engineering Bachelor of Bioscience, School of Life, Science and Technology Shanghai Jiao Tong University (SJTU), Shanghai, China email: jieyuan [at] uab.edu twitter: jieyuan1993 https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/b2f71e16-86d8-4903-b292-08e13c4f9b8f/tempImageQyooDf.jpg People - Yen Tran, MS B.S. International University of Nation University in Vietnam (Biotechnology) M.S. UAB Master of Science in Biotechnology email: yttran [at] uab.edu https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/015ca765-fd4f-463d-9f07-d3252ba75144/IMG_1590-2.JPG People - Ava Mattheyses Enjoys: Naps https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/42734728-bbea-4d31-bb9c-68db651dcf4b/IMG_1151.jpg People - Ru Ainslie https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/61d10025-ab9a-461d-b766-3f53b4f94a8f/IMG_20201203_184340.jpg People - Nigel Bartley http://www.mattheyseslab.com/research daily 0.75 2024-12-03 https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/76c46dc3-d297-47c3-8a72-77d63117ef2b/desmosomes.jpeg Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/ba0b734c-a2cb-49d3-8626-a170210e6e8a/Screenshot+2024-12-03+at+5.37.50%E2%80%AFPM.png Research - Make it stand out Tension-PAINT superresolution imaging As in Brockman et al Nature Methods 2020 https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/048375cd-a0ee-40aa-b86f-ef8f78e93427/Screenshot+2024-12-03+at+5.38.48%E2%80%AFPM.png Research - 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pollen https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458699329636-YHKQ21OR5FEPEGSMN5CO/tulip+blossom+petal.jpg Outreach - flower petal https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458699831487-5F8K5J58LC70K5M6U1SF/plant_1.jpg Outreach - leaf https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458783403387-PDCK9V8WQD0TEU29X6KV/IMG_3273.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458693410330-9YX7PK24JQFE8OYF18IB/pine_needle.jpg Outreach - pine needle https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458782911269-JCU0SAERNLWXVJFJ5NS7/IMG_3275.jpg Outreach - t-shirt https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817568593-3CY35KZVH5RN1Y1RTD0B/IMG_20100101_015931.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817580767-6JXAYRDIB0QICUA08FG9/IMG_20100101_015954.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817617581-3N8GROG7B2HTHNH0ZT0M/IMG_20100101_020433.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817631814-QZLAMAP1LUVSKJ1VFCBT/IMG_20100101_020659.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458610013260-7L0S12JOOVO4HJP8P6BW/image-asset.jpeg Outreach - paper towel https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817645353-YWOIYUO9CM70NUKNAOY7/IMG_20100101_021230.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458699211689-I9IV5SRYNUL4AC5TEXAO/image-asset.jpeg Outreach - dandelion head https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817659676-N8ZYPETSF5W3WPCA1OEI/IMG_20100101_022227.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1458610077135-B9Q0Z2HG7BP65SS9YDOD/image-asset.jpeg Outreach - paper towel https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817670455-DNJ6QDMSPFCVX2MV4RPH/IMG_20100101_022317.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817679841-RCUUKG8V3HXDX4GBA0M5/IMG_20100101_023413.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817686406-VHY68CCCEZ160A86LR8N/IMG_20100101_023603.jpg Outreach https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1497817727170-7SQ1N8SY8O0IIKLWACYZ/IMG_20100101_191514.jpg Outreach http://www.mattheyseslab.com/resources daily 0.75 2026-02-03 http://www.mattheyseslab.com/news-page daily 0.75 2020-07-31 http://www.mattheyseslab.com/publications daily 0.75 2026-02-05 https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/169f1286-ed42-4d49-bf4d-f298a7d32a2f/Screenshot+2026-02-05+at+11.09.33%E2%80%AFAM.png Publications - The desmoglein 2 interactome in primary neonatal cardiomyocytes Yang Li, Alexandra P. Campbell, Sahana Balasubramanian, Xuemei Zeng, Emma Porter, Pamela S. Cantrell, Mai Sun, Alexa L. Mattheyses, Adam V. Kwiatkowski Journal of Cell Science Manuscript Link Research Highlight Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/63b1de48-0c1c-4c77-966c-dfd5ce3d9afd/Screenshot+2025-08-30+at+11.17.09%E2%80%AFAM.png Publications - Super-Resolution Imaging Reveals Stretch-Induced Architectural Rearrangement of Desmoplakin in Desmosomes Leslie D. Seeley, Collin M. Ainslie, Mary Kathryn Sewell-Loftin, and Alexa L. Mattheyses BioRxiv Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/b0f684e0-6cfb-4577-a11c-d369ce4b1f42/Screenshot+2025-08-19+at+12.32.27%E2%80%AFPM.png Publications - The role of actin dynamics in vesicle formation during clathrin mediated endocytosis Jie Yuan, Yen T. B. Tran, Tomasz J. Nawara, and Alexa L. Mattheyses BioRxiv Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/3eec57e2-d131-4547-99ac-773407b0c8cd/joces_138_17.coverfig.png Publications - Desmoplakin tail domain position in the desmosomal plaque is isoform dependent Collin M Ainslie, Krishna Patel*, Yen T. B. Tran, Navaneetha Krishnan Bharathan, Volker Spindler, and Alexa L Mattheyses Journal of Cell Science Manuscript Link Research Highlight Link First Person: Collin Ainslie and Krishna Patel Link Cover Image Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/ba807a26-2f81-435d-8e50-37dc00e1c5d6/Screenshot+2024-10-24+at+2.22.05%E2%80%AFPM.png Publications - Illuminating cellular architecture and dynamics with fluorescence polarization microscopy Dean WF, Mattheyses AL Journal of Cell Science Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/642b451a-d803-4df4-ac8f-088c217a1389/Screen+Shot+2024-08-15+at+1.49.03+PM.jpg Publications - The Desmosome Comes into Focus Bharathan NK, Mattheyses AL, and Kowalczyk AP Journal of Cell Biology Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/ee2d1e06-d970-4ee3-bfd5-c0eb22df10ee/Screen+Shot+2023-12-07+at+9.28.12+AM.png Publications - OOPS: Object-Oriented Polarization Software for analysis of fluorescence polarization microscopy images Dean WF, Nawara TJ, Alberts RM, and Mattheyses AL PLoS Computational Biology Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/cfc6311a-e3ae-46bd-8705-11831c344d36/Screen+Shot+2024-04-04+at+9.51.12+AM.png Publications - Dsg2 ectodomain organization increases throughout desmosome assembly Dean WF*, Albert RM*, Nawara TJ, Ubil M, Beggs RR, and Mattheyses AL Cell Adhesion & Migration Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/5a7ae4b1-0cca-43cf-ad38-9dea062a444f/Screen+Shot+2024-01-03+at+8.59.38+AM.png Publications - Fluidic shear stress alters clathrin dynamics and vesicle formation in endothelial cells Nawara TJ, Yuan J, Seeley LD, Stzul E, and Mattheyses AL Biophysical Journal Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/6bff1f0a-a4ca-49ff-92f4-fb24c340cd35/image-asset.png Publications - Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics Ankenbauer KE, Rao TC, Mattheyses AL, and Bellis SL Journal of Biological Chemistry Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/5f0b3cc1-c15f-440c-961f-182ff5d57356/cover.jpeg Publications - DrSTAR: Tracking real-time nanometer axial changes Nawara TN, Dean WF, and Mattheyses AL Biophysical Journal Manuscript Link Cover Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/b6765715-f308-47dc-9e8f-34274c5e6dc5/1-s2.0-S1357272522001947-gr2_lrg.jpg Publications - Imaging nanoscale axial dynamics at the basal plasma membrane Nawara TN and Mattheyses AL The International Journal of Biochemistry and Cell Biology Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/73557859-5613-494d-8b09-f6058ab785f0/cover.tif.jpg Publications - Defining domain-specific orientational order in the desmosomal cadherins Dean WF and Mattheyses AL Biophysical Journal Manuscript Link Cover Link New and Notable Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/c97f2444-7d9a-4ec9-9c25-c958be980389/Screen+Shot+2022-04-08+at+2.49.38+PM.png Publications - ST6Gal-I-mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion Rao TC, Beggs RR, Ankenbauer KE, Hwang J, Ma VP, Salaita K, Bellis SL, and Mattheyses AL Journal of Biological Chemistry Manuscript Link UAB News Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/9e2ccb6c-5c0d-478a-b687-d81aa6d8b962/Screen+Shot+2022-04-08+at+2.43.18+PM.jpg Publications - Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis Tomasz J Nawara TJ, Williams 2nd YD, Rao TC, Hu Y, Sztul E, Salaita K, and Mattheyses AL Nature Communications Manuscript Link UAB News Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/cee2090d-e56b-400c-989d-3d90cdc3e02e/Screen+Shot+2022-04-01+at+11.12.32+AM.jpg Publications - Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion Rao TC and Mattheyses AL Journal of Visual Experiments Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/3f6c9b93-5b30-4d79-ba77-b4a84e60b79c/Screen+Shot+2022-04-08+at+2.24.36+PM.png Publications - Live-Cell Total Internal Reflection Fluorescence (TIRF) Microscopy to Investigate Protein Internalization Dynamics Rao TC, Nawara TJ, and Mattheyses AL Methods in Molecular Biology Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/70b100d7-72e4-4fbb-be3e-cd37b98d5be4/image-asset.jpeg Publications - Desmosomes undergo dynamic architectural changes during assembly and maturation Beggs RB. Rao TC, Dean WF, Kowalczyk AP, and Mattheyses AL Tissue Barriers Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/c3a3d356-9c41-4abd-bda3-ec56e8dd0d78/image-asset.png Publications - Turn-key super-resolution mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope Blanchard AT, Combs JD, Brockman JM, Kellner A, Glazier R, Su H, Bender R, Bazrafshan A, Chen W, Quach ME, Li R, Mattheyses AL, and Salaita K Nature Communications Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/b6fe9e26-a06b-4dd7-b4ff-0b03f611241c/Screen+Shot+2022-04-08+at+2.21.53+PM.png Publications - dSTORM Imaging and Analysis of Desmosome Architecture Beggs RR, Dean WF, and Mattheyses AL Methods in Molecular Biology Chapter Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/0dcc1078-0af3-484c-804f-66d6e5f105ef/image-asset.png Publications - Live-cell super-resolved PAINT imaging of piconewton cellular traction forces Brockman JM, Su H, Blanchard AT, Duan Y, Meyer T, Quach ME, Glazier R, Bazrafshan A, Bender RL, Kellner AV, Ogasawara H, Ma R, Schueder F, Petrich BG, Jungmann R, Li R, Mattheyses AL, Ke Y, and Salaita K Nature Methods https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/58056ea4-a552-45a5-aa22-c578df11c2c6/jcs_133_13_coverfig.png Publications - EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation Rao TC, Ma VP-Y, Blanchard A, Urner TM, Grandhi S, Salaita K, and Mattheyses AL Journal of Cell Science https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/ea756a5b-871a-4303-9ab3-3a39eb1d0b2b/image-asset.png Publications - Protein exchange regulates calcium independence of epithelial junctions Bartle EI, Rao TC, Beggs RR, Dean WF, Urner TM, Kowalczyk AP, and Mattheyses AL Journal of Cell Biology https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/cf2bc41c-194f-4634-b3ac-7273c2461a55/image-asset.png Publications - Variable Incidence Angle Linear Dichroism (VALiD): a technique for unique 3D orientation measurement of fluorescent ensembles Blanchard AT, Brockman JM, Salaita K, and Mattheyses AL Optics Express https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/c182bdc0-d0f0-4d84-a54b-0217b946a3d5/image-asset.png Publications - DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates Glazier R, Brockman JM, Bartle E, Mattheyses AL, Destaing O, and Salaita K Nature Communications https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/db607954-dbb8-4764-bf55-338e2a7dde05/image-asset.png Publications - Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid Henderson BW, Greathouse KM, Ramdas R, Walker CK, Rao TC, Bach SV, Curtis KA, Day JJ, Mattheyses AL, and Herskowitz JH Science Signaling https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/ea8fd3e1-f8d3-4b2a-af55-efeae8dde538/Screen+Shot+2022-04-05+at+1.47.45+PM.jpg Publications - The desmosome is a mesoscale lipid raft-like membrane domain Lewis JD, Caldara AL, Zimmer SE, Stahley SN, Seybold A, Strong NL, Frangakis AS, Levental I, Wahl JK 3rd, Mattheyses AL, Sasaki T, Nakabayashi K, Hata K, Matsubara Y, Ishida-Yamamoto A, Amagai M, Kubo A, and Kowalczyk AP Molecular Biology of the Cell https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/9eba8d5c-5da5-4cf1-ad8b-c354499d0fde/image-asset.png Publications - Bridging the gap: Super-resolution microscopy of epithelial cell junctions Bartle EI, Rao T, Urner TM, and Mattheyses AL Tissue Barriers https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/458ba2da-fce4-4f55-adab-a7c9c9bec21d/Screen+Shot+2022-04-07+at+11.12.24+AM.png Publications - Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells Hamilton JA, Wu Q, Yang P, Luo B, Liu S, Li J, Hong H, Fish EN, Mattheyses AL, Sanz I, Chatham WW, Hsu H, and Mountz JD Journal of Immunology https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/cb13af79-c70f-42aa-9756-ee6d4cb418ff/Screen+Shot+2022-04-07+at+11.13.36+AM.png Publications - Mapping the 3D Orientation of Piconewton Integrin Traction Forces Brockman JM, Blanchard AT, Ma VP-Y, Derricotte WD, Zhang Y, Fay ME, Lam WA, Evangelista FA, Mattheyses AL*, Salaita K* Nature Methods https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/738af3c1-8ef0-439c-9988-216db8c71292/Screen+Shot+2022-04-05+at+1.56.33+PM.png Publications - Desmoglein 3 Order and Dynamics in Desmosomes Determined by Fluorescence Polarization Microscopy Bartle EI, Urner TM, Raju SS, and Mattheyses AL Biophysical Journal https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/e8ac4f1b-2f48-4e61-9a16-5e3fd74c59d5/Screen+Shot+2022-04-07+at+11.15.25+AM.png Publications - High-resolution imaging of muscle attachment structures in Caenorhabditis elegans Qadota H, Matsunaga Y, Nguyen KCQ, Mattheyses A, Hall DH, and Benian GM Cytoskeleton https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/afdfe4a9-b66f-4f0a-9ff7-55d0346df1bf/Screen+Shot+2022-04-07+at+11.18.02+AM.jpg Publications - Molecular Organization of the Desmosome as Revealed by Direct Stochastic Optical Reconstruction Microscopy Stahely SN, Bartle EI, Atkinson CA, Kowalczyk AP, and Mattheyses AL Journal of Cell Science ”In this issue” featured article F1000 PRIME Feature https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/e4683296-d70e-4ebe-ae1b-57242127a1ea/Screen+Shot+2022-04-07+at+11.20.12+AM.png Publications - Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions Schlingmann B, Overgaard CE, Molina SA, Lynn KS, Mitchell LA, Dorsainvil White S, Mattheyses AL, Guidot DM, Capaldo CT, and Koval M Nature Communications https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/a43ed65b-ec31-4380-aa3b-526d6b3507d6/Screen+Shot+2022-04-07+at+11.21.05+AM.png Publications - The Sodium Chloride Cotransporter (NCC) and Epithelial Sodium Channel (ENaC) Associate Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS Biochemical Journal https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/0902f3ec-6c41-4ec1-8d54-234c8fee3675/Screen+Shot+2022-04-07+at+11.22.28+AM.png Publications - ROCK1 and ROCK2 Inhibition Alters Dendritic Spine Morphology in Hippocampal Neurons Swanger SA, Mattheyses AL, Gentry EG, and Herskowitz JH Cellular Logistics https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/32f4f6cf-5ded-4b40-b2ff-aa2aa7199dac/screenshot.jpg Publications - Nanoscale Optomechanical Actuators for Controlling Mechanotransduction in Living Cells Liu Z, Liu Y, Chang Y, Seyf HR, Henry A, Mattheyses AL, Yehl K, Zhang Y, Huang Z, and Salaita KS Nature Methods https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/61ac6bb4-206f-4e1f-a1c0-d507fc606853/Screen+Shot+2022-04-07+at+11.30.01+AM.png Publications - Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Pemphigus Vulgaris Patient Tissue Stahley SN, Warren MF, Feldman RJ, Swerlick RA, Mattheyses AL, and Kowalczyk AP Journal of Investigative Dermatology https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/32f33ee1-67cc-44c6-b72b-19eb502ba5a5/Screen+Shot+2022-04-07+at+11.30.59+AM.png Publications - Real-time Fluorescence Imaging with 20 nm Axial Resolution Stabley D, Oh T, Simon SM, Mattheyses AL*, and Salaita KS* Nature Communications https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/ad09791a-ce24-42f6-8cd1-752b4428939f/Screen+Shot+2022-04-08+at+2.26.25+PM.png Publications - Foster resonance energy transfer (FRET) microscopy for monitoring biomolecular interactions Mattheyses AL* and Marcus AI Protein-Protein Interactions: Methods and Applications Second Edition https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/0e4e8d68-779a-4a0a-9d8f-f51ad3919a8f/Screen+Shot+2022-04-07+at+11.32.29+AM.png Publications - The ARL2 GTPase is Required for Mitochondrial Morphology, Motility, and Maintenance of ATP Levels Newman LE, Zhou C, Mudigonda S, Mattheyses AL, Paradies E, Marobbio CMT, and Kahn RA Plos One Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/8b518609-1bdf-4033-9cd8-e42386891802/Screen+Shot+2022-04-07+at+11.33.50+AM.png Publications - Polarization-Controlled TIRFM With Focal Drift and Spatial Field Intensity Correction Johnson DS, Toledo-Crow R, Mattheyses AL, and Simon SM Biophysical Journal Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/2c8f28b3-15d6-4f08-888c-3a9566f7419b/Screen+Shot+2022-04-07+at+11.34.55+AM.png Publications - Desmosome assembly and disassembly are membrane raft-dependent Stahley SN, Saito M, Faundez V, Koval M, Mattheyses AL, and Kowalczyk AP Plos One Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/d6ba2cfb-3992-4adf-a18e-db39f7889f19/Screen+Shot+2022-04-08+at+2.29.01+PM.png Publications - Pharmacologic inhibition of ROCK2 suppresses amyloid-beta production in an Alzheimer disease mouse model Herskowitz JH, Feng Y, Mattheyses AL, Hales C, Higginbotham L, Duong D, Montine T, Troncoso JC, Thambisetty M, Seyfried N, Levey AI, and Lah JJ Journal of Neuroscience Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/c8237229-ad54-4915-a8e4-26a87bc749c4/image-asset.png Publications - The Chlamydomonas mutant pf27 is defective in radial spoke transport in the cilium Alford LM, Mattheyses AL, Hunter EL, Lin H, Dutcher SK, and Sale WS Cytoskeleton Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/cd72a2c4-082a-40cf-8877-722b0e3ca824/Screen+Shot+2022-04-07+at+11.37.25+AM.png Publications - Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis Zlatic SA, Grossniklaus EJ, Ryder PV, Salazar G, Mattheyses AL, Peden AA, and Faundez V Molecular Biology of the Cell Manuscript Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/a936af30-9214-40be-a0bf-360025a37e4b/Screen+Shot+2022-04-07+at+11.39.16+AM.png Publications - Conserved Spatial Organization of FG Domains in the Nuclear Pore Complex Atkinson CE, Mattheyses AL, Kampmann M, and Simon SM Biophysical Journal Manuscript Link Biophysical Journal New and Notable Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/c71362c2-9868-4c8b-9b20-61e01bcfc233/image-asset.png Publications - Signaling Network Crosstalk in Human Pluripotent Cells: a Smad2/3-Regulated Switch that Controls the Balance Between Self-Renewal and Differentiation Singh AM, Reynolds D, Cliff T, Ohtsuka S, Mattheyses AL, Sun Y, Menendez L, Kulik M, and Dalton S Cell Stem Cell Manuscript Link Comment in Cell Stem Cell Link https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/059ce276-0f0d-4e42-81bf-22dd9a86e56d/Screen+Shot+2022-04-04+at+9.02.21+PM.png Publications - Domain Topology of Nucleoporin Nup98 Within the Nuclear Pore Complex Chatel G, Desai SH, Mattheyses AL, Powers MA, and Fahrenkrog B Journal of Structural Biology Manuscript Link http://www.mattheyseslab.com/new-people-page daily 0.75 2022-03-31 http://www.mattheyseslab.com/people-1 daily 0.75 2022-04-01 https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1559785675542-RAAH4HQDX9DQDO2AFK0E/IMG_4709%2Bcopy.jpg People (Copy) https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1490906343607-ES6D4X42782NY6YDSECE/microscope+logo.png People (Copy) https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1557864421234-DYLNACQR60B94CMFUNW2/Will People (Copy) https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1550071181707-2S82ZXD2Z21QZVZXSVGY/Tom.JPG People (Copy) https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1613160484031-DDZZXSRU737PXLRP076Q/microscope+logo.png People (Copy) https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1567795821749-B46KS09NVF4FLVMASBOC/Rose%2BPicture%2B%25281%2529.jpg People (Copy) https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1596300846833-WBWWNZW7IC7ZR2ZSFM5C/image-asset.png People (Copy) https://images.squarespace-cdn.com/content/v1/55b1590de4b07de06424bb10/1622940264913-FC1TVKUADFLGIIAGP8N9/IMG_2900.jpeg People (Copy) - 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